Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents
نویسندگان
چکیده
منابع مشابه
Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior.
GABAergic hypothesis of anxiety was introduced many years ago, however, a limited number of supporting data were accumulated so far and the role of GABA(B) receptors in behavioral processes related to the anxiety disorders has not been resolved. In the present study, we examined anxiolytic activity of CGP 36742, a potent and selective GABA(B) receptor antagonist, in rodent tests/models. We have...
متن کاملAGI October 40/4
Blackshaw, L. Ashley, Esther Staunton, Anders Lehmann, and John Dent. Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G867– G874, 1999.—Transient lower esophageal sphincter (LES) relaxation is the major mechanism of gastroesophageal reflux. This study uses an established ferret model to evaluate GABA...
متن کاملInhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists.
Transient lower esophageal sphincter (LES) relaxation is the major mechanism of gastroesophageal reflux. This study uses an established ferret model to evaluate GABAB receptor agonists' ability to reduce triggering of transient LES relaxations. One hundred sixty manometric/pH studies were performed on 18 conscious ferrets. In untreated animals, intragastric infusion of 25 ml glucose (pH 3.5) le...
متن کاملGABA(B) receptor antagonist CGP-36742 enhances somatostatin release in the rat hippocampus in vivo and in vitro.
Here, we show the modulation of somatostatin functions in the hippocampus by the orally active 'cognition enhancer' GABA(B) receptor antagonist, (3-aminopropyl)n-butylphosphinic acid (CGP-36742), both in vivo and in vitro. Using high-pressure liquid chromatography-coupled electrospray mass spectrometry, we measured a two-fold increase in the extracellular level of somatostatin to CGP-36742 appl...
متن کاملImage Processing and CGP
Computerized image processing has been studied intensively for many years [32]. Because of the inherent complexity of the problem, stochastic optimization algorithms, including evolutionary algorithms, have been applied to improve existing image processing methods and develop new algorithms [4]. Section 6.2 deals with the automatic design of low-level image filters, ones comparable in quality t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2006
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706845